Author

Jake Hagen

Boston Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:benchmarking· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Guojie ZhongiD· 1 shared Hongbing Pan· 1 shared Tian LaniD· 1 shared Wendy K. ChungiD· 1 shared Yige ZhaoiD· 1 shared Yufeng SheniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperGenetic & Genomic Medicine

Guojie ZhongORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

A probabilistic graphical model for estimating selection coefficient of missense variants from human population sequence data

Yige Zhao, Tian Lan, Guojie Zhong, Jake Hagen, Hongbing Pan, Wendy K. Chung, Yufeng Shen

The paper introduces MisFit, a probabilistic graphical model to estimate selection coefficients of missense variants using population sequence data, showing improved performance in prioritizing disease-associated variants.

Nature Communications · May 20, 2025Peer-reviewedGenetic & Genomic Medicine