Genetic & Genomic MedicineNature CommunicationsPeer-reviewed
A probabilistic graphical model for estimating selection coefficient of missense variants from human population sequence data
Yige Zhao, Tian Lan, Guojie Zhong…·Yufeng Shen
The paper introduces MisFit, a probabilistic graphical model to estimate selection coefficients of missense variants using population sequence data, showing improved performance in prioritizing disease-associated variants.
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