Testing theoretical minimal genomes using whole-cell models
Joshua Rees-Garbutt, Jake Rightmyer, Oliver Chalkley, Lucia Marucci, Claire Suzanne Grierson
The paper tests theoretical minimal genomes for Mycoplasma genitalium using a whole-cell model, finding that simulated minimal gene sets fail to produce dividing cells, highlighting the need for species-specific low essential gene identification.
ACS Synthetic Biology · Jun 10, 2021Peer-reviewedSynthetic Biology