The N terminus of adhesion G protein-coupled receptor GPR126/ADGRG6 as allosteric force integrator
Jakob Mitgau, Julius Franke, Camilla Schinner, Gabriele Stephan, Sandra Berndt, Dimitris G. Placantonakis, Hermann Kalwa, Volker Spindler, Caroline Wilde, Ines Liebscher
This study identifies the N terminus of GPR126 as an allosteric force integrator that translates ECM binding into intracellular signals through distinct activation modes.
Frontiers in Cell and Developmental Biology · Jun 23, 2022Peer-reviewedMolecular Biology