Continuous sumatriptan exposure induces persistent trigeminovascular sensitisation and brain perfusion changes in a rat model of medication overuse headache.
James GA Hall, Fiona M. Boissonade, Aneurin J. Kennerley, Milena De Felice
This study shows that continuous sumatriptan exposure in rats causes reversible allodynia and persistent trigeminovascular sensitisation and reduced brain perfusion.
bioRxiv · May 29, 2026 · PreprintNeuroscience