A panel of TDP-43-regulated splicing events verify loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue
Maize C. Cao, Brigid Ryan, Jane Wu, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow, Emma L. Scotter
The paper identifies TDP-43-regulated splicing events in ALS brain tissue and validates them as markers of TDP-43 loss of function using in vitro models and bulk RNA-sequencing.
Neurobiology of Disease · Jul 30, 2023Peer-reviewedNeuroscience