Author

Maize C. Cao

University of AucklandORCID 0000-0002-5983-9228Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:statistical model· 4 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Approach:benchmark study· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

Emma L. ScotteriD· 4 shared Adam K. WalkeriD· 2 shared Maurice A. CurtisiD· 2 shared Richard L. M. FaulliD· 2 shared Adekunle T. BademosiiD· 1 shared Brigid RyaniD· 1 shared Catherine A. BlizzardiD· 1 shared Clinton P. TurneriD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersNeuroscience

Emma L. ScotterORCID

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4 papers

Recent·Most cited

Synaptic changes contribute to persistent extra-motor behaviour deficits in the rNLS8 TDP-43 mouse model of amyotrophic lateral sclerosis

Wei Luan, Rebecca San Gil, Lidia Madrid San Martin, Maize C. Cao, Florencia Vassallu, Heledd Brown-Wright, Adekunle T. Bademosi, Yi Jia Chye, Hao Yu Wu, Mu Sheen Chang, Emma L. Scotter, Catherine A. Blizzard, Lionel Muller Igaz, Adam K. Walker

This study identifies persistent extra-motor behavioural deficits in rNLS8 TDP-43 mice, linked to synaptic gene expression and splicing changes that persist even after motor recovery.

bioRxiv · Mar 4, 2025 · PreprintNeuroscience

A panel of TDP-43-regulated splicing events verify loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue

Maize C. Cao, Brigid Ryan, Jane Wu, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow, Emma L. Scotter

The paper identifies TDP-43-regulated splicing events in ALS brain tissue and validates them as markers of TDP-43 loss of function using in vitro models and bulk RNA-sequencing.

Neurobiology of Disease · Jul 30, 2023Peer-reviewedNeuroscience

Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain

Molly E. V. Swanson, Miran Mrkela, Helen C. Murray, Maize C. Cao, Clinton P. Turner, Maurice A. Curtis, Richard L. M. Faull, Adam K. Walker, Emma L. Scotter

This study examines microglial activation and TDP-43 pathology in ALS brains, finding increased CD68 and L-ferritin expression in human and mouse models linked to pTDP-43 aggregation.

bioRxiv · Feb 14, 2023 · PreprintNeuroscience

Novel and known transcriptional targets of ALS/FTD protein TDP-43: Meta-analysis and interactive graphical databases

Maize C. Cao, Emma L. Scotter

The paper identifies novel and known TDP-43 targets through meta-analysis of RNA-seq data from TDP-43 knockdown models and validates them in ALS/FTD brain tissue.

Disease Models & Mechanisms · Aug 10, 2022Peer-reviewedNeuroscience