Inferring Local Protein Structural Similarity from Sequence Alone
Zinnia Ma, Javier Espinoza Herrera, Elsy Buitrago-Delgado, Neville P. Bethel, Adrián Jinich
This paper shows that protein language models can detect local structural similarities from sequence data without 3D models, identifying aligned regions through cosine similarity of residue embeddings.
Journal of Chemical Information and Modeling · May 2, 2026Peer-reviewedBioinformatics