Neville P. Bethel

The paper investigates how NFκB (RelA/p50) achieves high-affinity binding to partial consensus DNA sequences through structural rearrangements and dynamic interactions.

This paper designs de novo minibinders that inhibit blood-stage malaria replication with nanomolar potency by targeting the RH5-basigin interaction.

This paper presents a modular strategy to design programmable, highly porous protein crystals with tunable architectures and composition, enabling applications in catalysis and biomedicine.

This study shows that computationally designed proteins can template and confine hydroxyapatite mineralization, providing a framework for programmable protein-guided mineralization.

This paper shows that protein language models can detect local structural similarities from sequence data without 3D models, identifying aligned regions through cosine similarity of residue embeddings.

This paper introduces RemoteFoldSet and the Structural Awareness score to benchmark how well protein language models encode structural information.

The paper introduces a modular bond-centric design approach for protein assemblies, demonstrating the successful creation of multiple polyhedral cages, 2D arrays, and 3D lattices with high success rates.

This paper computationally designs self-assembling protein rotary machines that sample internal rotational degrees of freedom based on energy landscapes.

The paper identifies extremotolerant proteins that form condensates and protect human cells from apoptosis, including a synthetic protein and a region of ApoE.