Structural insights into the inhibition of sickle hemoglobin polymerization by asymmetric hemoglobin tetramer HbFS (α2γβS)
Aastha Baliyan, Neha Yadav, Nihar Ranjan Mishra, Santosh Kumar Mondal, Kalyan Goswami, Jayeeta Bhowmick, Amit Kumar Mandal
This study investigates how elevated fetal hemoglobin (HbF) inhibits sickle hemoglobin (HbS) polymerization using mass spectrometry techniques, revealing conformational changes in HbFS that reduce polymerization.
bioRxiv · Jun 7, 2026 · PreprintBiochemistry