Preserved synaptic architecture but impaired ketamine-induced synaptic plasticity of layer 5 pyramidal neurons in the aged frontal cortex
Irene F. Ugidos, JC Iglesias, Sebastian Milanes, Fatemeh Farahani, Ricardo Mostany
The paper examines age-related changes in synaptic plasticity of layer 5 pyramidal neurons in the frontal cortex, finding preserved baseline spine structure but impaired ketamine-induced spinogenesis in aged mice.
bioRxiv · Sep 2, 2025 · PreprintNeuroscience