Phenome-wide and proteomic analysis of APOE alleles across different ancestries in the All of Us Research Program
Alejandro Mejía García, Pablo Valderrama‐Carmona, Thomas M Zheng, Zhenqian Wang, Hsuan Megan Tsao, Jean Jung, Carlos A. Orozco, Chen‐Yang Su, Sirui Zhou
This study identifies ancestry-specific APOE effects on phenotypes and plasma proteins in diverse populations, highlighting the need for ancestry-aware risk interpretation.
medRxiv · Sep 28, 2026 · PreprintGenetic & Genomic Medicine