A heterohexameric protein consisting of six linked single-domain antibodies is highly protective for BoNT/A, BoNT/B and BoNT/E exposures
Jean Mukherjee, Jacqueline M. Tremblay, Michelle E. Debatis, Alexa D. Foss, Junya Awata, Charles B. Shoemaker
This study develops heterohexameric proteins with six linked VHHs that neutralize BoNT/A, B, and E, showing full protection in mice against high toxin doses.
bioRxiv · Mar 2, 2021 · PreprintMolecular Biology