Elucidating cancer cachexia-mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle
Nora Hosny, Houda Cohen, Mohamed Waleed Elafany, Jeff Schreifels, John Bauer, Rishi Gulati, Brian R. Thompson, Julia C. Liu, Joseph M. Metzger
This study investigates cachexia-induced cardiac wasting using human iPSC-derived cardiac muscle, identifying the Atrogin-1/Calcineurin A/NFAT signaling pathway as a key driver of cardiac atrophy and functional impairments.
bioRxiv · Aug 18, 2025 · PreprintMolecular Biology