Joseph M. Metzger

This study investigates cachexia-induced cardiac wasting using human iPSC-derived cardiac muscle, identifying the Atrogin-1/Calcineurin A/NFAT signaling pathway as a key driver of cardiac atrophy and functional impairments.

This study investigates the effects of the R403Q beta-myosin mutation on cardiac myocyte calcium homeostasis and contractility, finding increased intracellular calcium and hyper-contractility.