Comparative Analysis of Pathology Foundation Models for Automated Detection of Tertiary Lymphoid Structures in H&E-Stained Digital Pathology Images
Meijian Guan, Yu Sun, Merzu Kebede Belete, Anantharaman Muthuswamy, Maximilian Farma, Jenny Kaufmann, Mirna Lechpammer, Sriram Sridhar, Brandon W. Higgs, Han Si
This study evaluates pathology foundation models for detecting tertiary lymphoid structures in cancer tissues, finding strong performance in PDAC but challenges in HNSCC due to tumor heterogeneity.
Computational and Structural Biotechnology Journal · Mar 1, 2026Peer-reviewedBioinformatics