Transcriptomic signatures predict regulators of drug synergy and clinical regimen efficacy against Tuberculosis
Shuyi Ma, Suraj Jaipalli, Jonah Larkins‐Ford, Jenny Lohmiller, Bree B. Aldridge, David R. Sherman, Sriram Chandrasekaran
The paper develops a computational model to identify synergistic anti-TB drug combinations using transcriptomic data and validates its predictions with clinical trial data.
mBio · Nov 11, 2019Peer-reviewedSystems Biology