Non-equilibrium strategies enabling ligand specificity by signaling receptors
Andrew Goetz, Jeremy Barrios, Ralitsa Radostinova Madsen, Purushottam D. Dixit
The paper introduces a non-equilibrium model explaining how signaling receptors achieve ligand specificity through multi-site phosphorylation and degradation, showing that intermediate-affinity ligands maximize network activity.
eLife · Oct 29, 2025Peer-reviewedSystems Biology