Andrew Goetz

Endocytosis shapes extracellular chemical gradients in autonomous cell-cell attraction

The paper shows that ligand endocytosis enhances directional information in cell-cell attraction by reshaping extracellular gradients.

Directional Sensing by Eukaryotic Receptors

This paper introduces a reaction-diffusion model called LAGS to show that eukaryotic receptors can perform directional sensing through lateral diffusion, basal activity, and active degradation, without relying on downstream signaling pathways.

Non-equilibrium strategies enabling ligand specificity by signaling receptors

The paper introduces a non-equilibrium model explaining how signaling receptors achieve ligand specificity through multi-site phosphorylation and degradation, showing that intermediate-affinity ligands maximize network activity.

Computational modeling of drug response identifies mutant-specific constraints for dosing panRAF and MEK inhibitors in melanoma

This study uses computational modeling and preclinical data to identify optimal dosing strategies for panRAF and MEK inhibitors in melanoma, revealing distinct dose requirements based on NRAS vs BRAF mutations.

The ability to sense the environment is heterogeneously distributed in cell populations

The paper quantifies the distribution of sensing abilities in cell populations using an information theoretic framework and shows most cells achieve better input resolution than the average.