Dissecting the molecular origins of opalescence and phase separation in mAb formulations and their relation to aggregation
Inna Brakti, Samuel Lenton, Marco Polimeni, Hannes Ausserwӧger, Rob M. Scrutton, Anette Henriksen, Nikolai Lorenzen, Martin Nors Pedersen, Jesper Soendergaard Marino, Fátima Herranz-Trillo, Ann E. Terry, Tuomas P. J. Knowles, Minna Groenning Jensen, Vito Foderà
This paper investigates the molecular mechanisms of opalescence and liquid-liquid phase separation in mAb formulations and shows they are decoupled from aggregation.
bioRxiv · Aug 29, 2025 · PreprintBiophysics