Nikolai Lorenzen

Prediction of Antibody Non-Specificity using Protein Language Models and Biophysical Parameters

This paper predicts antibody non-specificity using protein language models and biophysical parameters, showing that heavy variable domains and isoelectric point are key predictors.

Biomolecular condensates sustain pH gradients at equilibrium driven by charge neutralisation

This study shows that biomolecular condensates can sustain pH gradients without energy input by neutralizing charges, revealing their role in creating pH microenvironments.

Dissecting the molecular origins of opalescence and phase separation in mAb formulations and their relation to aggregation

This paper investigates the molecular mechanisms of opalescence and liquid-liquid phase separation in mAb formulations and shows they are decoupled from aggregation.