Profiling plasma extracellular vesicle-derived microRNAs for noninvasive diagnosis of alpha-1 antitrypsin deficiency associated liver disease
Regina A. Oshins, Zhiguang Huo, Brittney Poole, Virginia Clark, Huiping Zhou, Jesse West, Matthew Wheeler, Mahya Aghaee, Mei He, Mark Brantly, Nazli Khodayari
This study identifies miRNA biomarkers in plasma extracellular vesicles for noninvasive detection of AATD liver disease, achieving an AUC of 0.751 with a four-miRNA model.
bioRxiv · Aug 31, 2023 · PreprintMolecular Biology