Ovarian hormonal state at exercise initiation interacts with nigrostriatal circuitry to determine long-term voluntary exercise behavior
Margaret K. Tanner, Kamryn M. Korth, Alyssa A. Hohorst, Juliet R. Freund, Jessica D. Westerman, Carolina Sanchez Mendoza, Benjamin N. Greenwood
This study shows that the ovarian hormonal state at the start of voluntary wheel running in female rats affects both initial and long-term exercise behavior, with dopamine signaling in the nigrostriatal circuit playing a key role.
bioRxiv · Jun 22, 2026 · PreprintNeuroscience