Pharmacology & ToxicologyAntimicrobial Agents and ChemotherapyPeer-reviewed
A Stochastic Simulation-Based Approach to Inform Relapsing Mouse Model (RMM) Study Design for Non-Clinical Assessment of Tuberculosis
James Clary, Jessica K. Roberts, Debra L. Hanna…·Alexander K. Berg
This paper evaluates alternative study designs for relapsing mouse models of tuberculosis to reduce animal use while maintaining accuracy in estimating treatment efficacy.
3 citations