Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively
Andrew R Wood, Jessica Tyrell, Robin Beaumont, Samuel E Jones, Marcus A Tuke, Katherine S Ruth, The GIANT consortium, Hanieh Yaghootkar, Rachel Freathy, Anna Murray, Timothy M Frayling, Michael N Weedon
The paper identifies recessive genetic effects at FTO and CDKAL1 loci for obesity and type 2 diabetes using dominance deviation models in large cohorts.
Diabetologia · Mar 10, 2016Peer-reviewedGenetics