Author

Timothy M Frayling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetics· 5 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:GWAS summary statistics· 6 Organism:human· 6 Approach:statistical model· 6 Research Focus:GWAS / association mapping· 5 Research Focus:benchmarking· 1

Frequent Co-Authors

Andrew R Wood· 6 shared Marcus A Tuke· 5 shared Anna MurrayiD· 4 shared Hanieh YaghootkariD· 4 shared Katherine S Ruth· 4 shared Michael N Weedon· 4 shared Rachel M Freathy· 4 shared Samuel E Jones· 4 shared

Activity by Year

2015-2016 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersGenetics

Andrew R Wood

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

Jessica Tyrrell, Andrew R Wood, Ryan M Ames, Hanieh Yaghootkar, Robin N. Beaumont, Samuel E. Jones, Marcus A Tuke, Katherine S. Ruth, Rachel M Freathy, George Davey Smith, Stéphane Joost, Idris Guessous, Anna Murray, David P. Strachan, Zoltán Kutalik, , Timothy M Frayling

The paper tests if socioeconomic position amplifies genetic risk for obesity using UK Biobank data and finds gene-environment interactions with socioeconomic deprivation.

bioRxiv · Sep 13, 2016 · PreprintGenetics

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

Andrew R Wood, Jessica Tyrell, Robin Beaumont, Samuel E Jones, Marcus A Tuke, Katherine S Ruth, The GIANT consortium, Hanieh Yaghootkar, Rachel Freathy, Anna Murray, Timothy M Frayling, Michael N Weedon

The paper identifies recessive genetic effects at FTO and CDKAL1 loci for obesity and type 2 diabetes using dominance deviation models in large cohorts.

Diabetologia · Mar 10, 2016Peer-reviewedGenetics

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

Samuel E Jones, Jessica Tyrrell, Andrew R Wood, Robin N Beaumont, Katherine S Ruth, Marcus A Tuke, Hanieh Yaghootkar, Youna Hu, Maris Teder-Laving, Caroline Hayward, Till Roenneberg, James F Wilson, Fabiola Del Greco, Andrew A Hicks, Chol Shin, , Michael N Weedon

bioRxiv · Feb 2, 2016Genetics

HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

Luke C Pilling, Janice L Atkins, Kirsty Bowman, Samuel E Jones, Jessica Tyrrell, Robin N Beaumont, Katherine S Ruth, Marcus A Tuke, Hanieh Yaghootkar, Andrew R Wood, Rachel M Freathy, Anna Murray, Michael N Weedon, Luting Xue, Kathryn Lunetta, , David Melzer

This study identifies genetic variants associated with parental longevity using GWAS on 75,000 UK Biobank participants, finding multiple protective factors linked to longer lifespan.

bioRxiv · Feb 1, 2016Genomics

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

Guo-Bo Chen, Sang Hong Lee, Matthew R Robinson, Maciej Trzaskowski, Zhi-Xiang Zhu, Thomas W Winkler, Felix R Day, Damien C Croteau-Chonka, Andrew R Wood, Adam E Locke, Zoltán Kutalik, Ruth J F Loos, Timothy M Frayling, Joel N Hirschhorn, Jian Yang, , Peter M Visscher

This study introduces metrics and tools to assess quality control in genome-wide association meta-analyses using summary statistics from multiple cohorts.

bioRxiv · Dec 6, 2015 · PreprintGenetics

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

Katherine S Ruth, Robin N Beaumont, Jessica Tyrrell, Samuel E Jones, Marcus A Tuke, Hanieh Yaghootkar, Andrew R Wood, Rachel M Freathy, Michael N Weedon, Timothy M Frayling, Anna Murray

This study identifies a genetic variant lowering FSH levels that is associated with longer menstrual cycles, later menopause, and reduced endometriosis risk, but not with PCOS or male infertility.

bioRxiv · Oct 19, 2015Genetics