Systematic Analysis of Immune Changes after B-cell Depletion in Autoimmune Multiple Sclerosis
Jessica Wei, Jeonghyeon Moon, Yoshiaki Yasumizu, Le Zhang, Khadir Radassi, Nicholas Buitrago-Pocasangre, M. Elizabeth Deerhake, Nicholas Strauli, Alan Chan, Ann Herman, Rosetta Pedotte, Catarina Raposo, Björn Tackenberg, Isaiah Yim, Jenna Pappalardo, , David A. Hafler
This study uses single-cell RNA sequencing to analyze immune changes after B-cell depletion in MS patients, revealing cell type-specific effects on macrophages, monocytes, and T cells.
bioRxiv · Feb 7, 2024 · PreprintImmunology