Calpain-4 Knockdown Modulates Cholesterol Metabolism and LXRα Nuclear Localization in Alcohol-Related Liver Disease
Noriko Kitano, Jiang Li, Sam Taborski, Charis-Marie Vanderpuye, Pooja Muddasani, Sudrishti Chaudhary, Jia Jun Liu, Silvia Liu, Juliane I. Beier, Josepmaria Argemí, Ramon A. Bataller, Gavin E. Arteel
This study shows that Calpain-4 knockdown reduces cholesterol levels and relocalizes LXRα to the nucleus in alcohol-related liver disease.
bioRxiv · Oct 9, 2025 · PreprintMolecular Biology