Data-driven dynamic modelling identifies polyploidisation as key process in cell cycle progression upon DNA damage
Elsje J Burgers, Muriel M. Heldring, Lukas S. Wijaya, Tamara Y Danilyuk, Jiahang Su, Sebastiaan J Molenaar, Peter Bouwman, Sylvia E. Le Dévédec, Bob van de Water, Joost B. Beltman
The paper develops a mathematical model to study how DNA damage affects cell cycle progression, finding that polyploidisation is a key response in HepG2 cells.
bioRxiv · Aug 14, 2025 · PreprintSystems Biology