Sord deficient rats develop a motor-predominant peripheral neuropathy unveiling novel pathophysiological insights
Adriana P. Rebelo, Clemer Abad, Maike Franziska Dohrn, Jian J. Li, Ethan Kim Tieu, Jessica Medina, Christopher Yanick, Jingyu Huang, Brendan C. Zotter, Juan I. Young, Mario Saporta, Steven S. Scherer, Katherina Walz, Stephan L. Zuchner
This study generates a Sord knockout rat model to study SORD deficiency, revealing motor-predominant neuropathy with elevated sorbitol and neurofilament light chain levels.
Brain · Mar 26, 2024Peer-reviewedNeuroscience