Structural and Functional Insights into GGCX-FIX Interaction: Implications for Vitamin K-Dependent Bleeding Disorders
Kang Liu, Shixin Li, Jiangbo Tong, Nan Jiang, Minwen Hong, Yi Gu, Luju Chen, Dan Liang, Yongchao Jin, Yuan Zhao, Dongmei Hou, Jinlin Huang, Jian‐Ke Tie, Zhenyu Hao
This study identifies key functional regions of GGCX and their interactions with FIX using AlphaFold 3 and simulations, revealing residues critical for carboxylation and vitamin K epoxidation.
bioRxiv · Feb 18, 2025 · PreprintPathology