Author

Jian‐Ke Tie

University of North Carolina at Chapel HillORCID 0000-0002-8447-3408Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Dan Liang· 1 shared Dongmei Hou· 1 shared Jiangbo Tong· 1 shared Jinlin Huang· 1 shared Kang Liu· 1 shared Luju Chen· 1 shared Minwen Hong· 1 shared Nan JiangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPathology

Dan Liang

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1 paper

Recent·Most cited

Structural and Functional Insights into GGCX-FIX Interaction: Implications for Vitamin K-Dependent Bleeding Disorders

Kang Liu, Shixin Li, Jiangbo Tong, Nan Jiang, Minwen Hong, Yi Gu, Luju Chen, Dan Liang, Yongchao Jin, Yuan Zhao, Dongmei Hou, Jinlin Huang, Jian‐Ke Tie, Zhenyu Hao

This study identifies key functional regions of GGCX and their interactions with FIX using AlphaFold 3 and simulations, revealing residues critical for carboxylation and vitamin K epoxidation.

bioRxiv · Feb 18, 2025 · PreprintPathology