Coronavirus envelope protein drives iron sensing disorder by hijacking the TAp73-FDXR axis
Mingjun Zhu, Leyu Hu, Xingwei Fu, Boshui Yuan, Guiwen Guan, Lu Han, Zesheng Rong, Ru Tian, Gen Li, Muzi Du, Yan Ma, Ning Xu, Haixin Liu, Haolun Tian, Xinhuan Yin, , Dewen Tong
This study identifies how the coronavirus envelope protein disrupts the TAp73-FDXR axis to cause iron overload, leading to iron deficiency perception and tissue damage, and presents a therapeutic molecule to counteract this effect.
bioRxiv · Mar 25, 2026 · PreprintMicrobiology