Protein Domain Hotspots Reveal Functional Mutations across Genes in Cancer
Martin L Miller, Ed Reznik, Nicholas P Gauthier, Bülent Arman Aksoy, Anil Korkut, Jianjion Gao, Giovanni Ciriello, Nikolaus Schultz, Chris Sander
The paper identifies rare functional mutations in cancer by mapping them to protein domain hotspots across 22 tumor types, revealing both known and novel mutations with functional implications.
Cell Systems · Sep 1, 2015Peer-reviewedGenomics