Giovanni Ciriello

A multi-method approach for proteomic network inference in 11 human cancers

This study evaluates 13 network inference methods on RPPA proteomic data from 11 cancers to identify common protein-protein interactions across tumor types.

Protein Domain Hotspots Reveal Functional Mutations across Genes in Cancer

The paper identifies rare functional mutations in cancer by mapping them to protein domain hotspots across 22 tumor types, revealing both known and novel mutations with functional implications.

Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

The paper identifies cancer driver pathways by detecting mutual exclusivity patterns in genomic alterations across TCGA datasets, revealing previously unreported driver events.

Cancer-associated recurrent mutations in RNase III domains of DICER1

The paper identifies recurrent DICER1 mutations in cancer that disrupt miRNA processing and cause mRNA expression imbalances, contributing to oncogenesis.