Nuclear Translocation of SIRT4 Mediates Deacetylation of U2AF2 to Modulate Renal Fibrosis Through Alternative Splicing-mediated Upregulation of CCN2
Guangyan Yang, Jiaqing Xiang, Xiaoxiao Yang, Xiaomai Liu, Yanchun Li, Lixing Li, Lin Kang, Zhen Liang, Shu Yang
This study identifies SIRT4 as a regulator of CCN2 expression through U2AF2 deacetylation and alternative splicing, contributing to renal fibrosis.
bioRxiv · Apr 30, 2024Molecular Biology