Multi-omics integration of malignant peripheral nerve sheath tumors identifies potential targets based on chromosome 8q status
Belinda B. Garana, Jiawan JC Wang, Simge Acar, Gorkem Oztosun, Stavriani C. Makri, Dana C. Borcherding, Ying S. Zou, Chelsea M. Hutchinson-Bunch, Marina A. Gritsenko, Paul Piehowski, Christine A. Pratilas, Angela C. Hirbe, Sara J.C. Gosline
This study integrates multi-omics data from MPNSTs to identify drug targets based on chromosome 8q status, suggesting PLK1 and EGFR inhibitors could be effective in different subtypes.
bioRxiv · Jan 27, 2026 · PreprintCancer Biology