On-target toxicity of GSPT1 molecular glue degraders in mice
Yi-Sheng Pu, YiMin He, XiaoFan Wei, Yu Long Zhang, JieFu Fang, Bo Peng, Yong Cang
The paper investigates the on-target toxicity of GSPT1 molecular glue degraders in mice, showing that GSPT1 depletion causes severe systemic toxicity, which is rescued by a degradation-resistant mutant.
bioRxiv · Feb 16, 2026 · PreprintMolecular Biology