ADAR1 orchestrates the ZBP1-mediated PANoptosis and heart transplant rejection
Haitao Lü, Jifu Jiang, Xuyan Huang, Aaron R. Haig, Lakshman Gunaratman, Anthony M. Jevnikar, Zhu‐Xu Zhang
This study shows ADAR1 regulates ZBP1-RIPK3 complex activation to mediate PANoptosis in heart transplant rejection, with ZBP1 inhibition reducing graft injury and improving survival.
bioRxiv · Sep 5, 2024 · PreprintMolecular Biology