Polygenic prediction of treatment efficacy with causal transfer learning
Jiacheng Miao, Jin Mu, Xiaoyu Yang, Jason M. Fletcher, Lauren Schmitz, Qiongshi Lu
This paper introduces a statistical framework to identify genetically driven heterogeneous treatment effects using causal transfer learning, applied to RCTs to find key determinants of treatment efficacy.
medRxiv · Oct 15, 2025 · PreprintGenetic & Genomic Medicine