Lauren Schmitz

This paper introduces a statistical framework to identify genetically driven heterogeneous treatment effects using causal transfer learning, applied to RCTs to find key determinants of treatment efficacy.

This study introduces PIGEON, a statistical framework for gene-environment interaction analysis using summary statistics, showing its superiority in multiple analytic settings.

This paper introduces QUAIL, a model for detecting genetic variants affecting trait variability, and finds 11 novel BMI vQTL with interactions with physical activity and sedentary behavior.

This study examines psychopathology structure and genetic associations in older adults, finding a general factor of psychopathology and limited domain-specific genetic associations.

This study compares 11 epigenetic aging clocks using DNA methylation data from human tissues and cells, finding differences in CpG characteristics, tissue specificity, and gene network associations.

Polygenic scores built 434 ways in Health and Retirement Study (HRS) participants varied widely in variance explained and inter-score correlation; European-derived weights underperformed in non-Hispanic Blacks.