AI-Guided Dual Strategy for Peptide Inhibitor Design Targeting Structural Polymorphs of α-Synuclein Fibrils
Jinfang Duan, Haoyu Zhang, Chuanqi Sun
This paper designs peptide inhibitors targeting α-synuclein fibril polymorphs using AI and cryo-EM data, finding two peptides that inhibit fibrillation effectively.
Cells · Dec 3, 2025Peer-reviewedNeuroscience