Vagus Nerve Stimulation Ameliorates Epilepsy via a Gut Microbiota-Butyrate-Vagus Nerve-Brain Axis
Long Zeng, Junjie Zou, Yuting Xu, Jingjing Kong, Qingshan Xiao, Zizhang Cheng, Minghan Xie, Yuhui Wan, Anbo Zhang, Yunhao Luo, Yuhan Huang, Yanjuan Ye, Jine Yuan, Shan Xue, Xizhong Zhou, , Yanwu Guo
This paper shows that vagus nerve stimulation reduces seizures by altering gut microbiota and butyrate levels through a vagus nerve-dependent pathway.
bioRxiv · Feb 23, 2026 · PreprintNeuroscience