Oscillating Hypercapnia Induces Neural Abundant Protein Efflux and Potential Depletion in Health and Chronic Traumatic Brain Injury
Andrew Mayer, Tracey V. Wick, Upasana Nathaniel, Sephira G. Ryman, Divyasree Sasi Kumar, Rebekah Mannix, Samuel Miller, Josef M. Ling, Timothy Bradley Meier, Kaitlyn Warren, Harm Jan van der Horn, Vadim S. Zotev, Jingshu Wu, Pawani Chauhan
This study shows that hypercapnia temporarily increases brain-to-blood protein clearance in TBI and healthy individuals, with effects moderated by brain atrophy.
Journal of Cerebral Blood Flow & Metabolism · May 28, 2026Peer-reviewedNeuroscience