Author

Jingyan Bai

Central South University

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Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Jiayi YangiD· 1 shared Min GaniD· 1 shared Qi YiniD· 1 shared Shengjie SuniD· 1 shared Tianwen Shao· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperBiophysics

Jiayi YangORCID

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1 paper

Recent·Most cited

Divergent conformational mechanisms of JAK2V617F and TYK2V678F mutations in Thrombocythemia and related disorders: Molecular Dynamics insights into pathway activation and therapeutic targeting

Tianwen Shao, Min Gan, Qi Yin, Jingyan Bai, Jiayi Yang, Shengjie Sun

This study uses molecular dynamics simulations to analyze how JAK2V617F and TYK2V678F mutations sustain JAK-STAT pathway activation through distinct conformational changes, providing insights for therapeutic targeting.

bioRxiv · May 16, 2025 · PreprintBiophysics