Author

Shengjie Sun

Central South UniversityORCID 0009-0001-2178-0654Unclaimed ORCID profile · follow to get notified of new preprints

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Shengjie Sun1 paper · Tianjin Agricultural University

Biology Disciplines

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Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

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Jiayi YangiD· 1 shared Jingyan Bai· 1 shared Min GaniD· 1 shared Qi YiniD· 1 shared Tianwen Shao· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiophysics

Jiayi YangORCID

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1 paper

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BiophysicsbioRxivPreprintMay 16, 2025

Divergent conformational mechanisms of JAK2V617F and TYK2V678F mutations in Thrombocythemia and related disorders: Molecular Dynamics insights into pathway activation and therapeutic targeting

Tianwen Shao, Min Gan, Qi Yin…·Shengjie Sun

This study uses molecular dynamics simulations to analyze how JAK2V617F and TYK2V678F mutations sustain JAK-STAT pathway activation through distinct conformational changes, providing insights for therapeutic targeting.

1 citation

humanprotein structure

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