Rewiring of 3D Enhancer-Promoter Interactome Underlies Diabetic Endothelial Dysfunction
Lei Jiang, Xiaofei Yang, Ruixin Zhou, Shiyu Zheng, Yelan Li, Ning Tan, Siim Pauklin, Sakthivel Sadayappan, C. Zhang, Wanzi Hong, Mingyang Wang, Hannah Morgan, Keara Little, Guochang Fan, Furong Li, , Yuliang Feng
The paper identifies RBBP6-mediated degradation of JUNB as a mechanism causing 3D enhancer-promoter disruption and endothelial dysfunction in diabetes.
bioRxiv · Mar 5, 2026 · PreprintGenomics