Anil Goud Jegga

Rewiring of 3D Enhancer-Promoter Interactome Underlies Diabetic Endothelial Dysfunction

The paper identifies RBBP6-mediated degradation of JUNB as a mechanism causing 3D enhancer-promoter disruption and endothelial dysfunction in diabetes.

Single-vessel transcriptome map pathological landscapes and reveal NR2F2-mediated smooth muscle cell phenotype acquisition in capillary malformations

The paper constructs a spatial transcriptomic atlas of capillary malformations, identifies EndMT and AJ disruption, and shows NR2F2 drives SMC phenotype acquisition in vascular lesions.

Wilms tumor 1 impairs apoptotic clearance of fibroblasts in distal fibrotic lung lesions

This study shows WT1 promotes fibroblast survival and ECM production in IPF by impairing apoptotic clearance.

Differential Expression and Microsystem Physiology Reveal Predominant and Drug Reversible CFTR-Related Defects in Idiopathic Pancreatitis

This study identifies CFTR-related defects in idiopathic pancreatitis and shows that ivacaftor can reverse these defects in patient-derived models.

Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer Disease

This study examines the acute effects of increasing protein O-GlcNAcylation in mice brains using OGA inhibitor Thiamet G, identifying transcriptome changes opposite to those seen in Alzheimer's disease.

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell disease.

This study shows that neuroinflammation and lipid dysregulation contribute to social stress-induced cognitive deficits in sickle cell disease using a mouse model.

GraMDTA: Multimodal Graph Neural Networks for Predicting Drug-Target Associations

GraMDTA predicts drug-target associations using multimodal graph neural networks combining structural and knowledge graph representations.

MGATRx: Discovering Drug Repositioning Candidates Using Multi-view Graph Attention

MGATRx identifies drug repositioning candidates by integrating drug and disease annotations using a multi-view graph attention network, outperforming existing methods and showing translational potential.

Structural and cellular transcriptome foundations of human brain disease

The paper identifies five major transcriptional patterns of brain disease risk genes across the adult human brain and highlights species-specific differences in psychiatric and substance abuse-related diseases.

Secondary analysis of transcriptomes of SARS-CoV-2 infection models to characterize COVID-19

The paper performs secondary transcriptomic analysis of SARS-CoV-2 infection models to identify conserved differentially expressed genes and their associations with COVID-19-related traits and pathways.

Pan-transcriptome-based Candidate Therapeutic Discovery for Idiopathic Pulmonary Fibrosis

This study identifies 77 potential therapeutics for IPF by analyzing gene expression and drug-perturbagen connectivity, including FDA-approved drugs and clinical trial compounds.

PP-2, a src-kinase inhibitor, is a potential corrector for F508del-CFTR in cystic fibrosis

The paper identifies PP-2, a src-kinase inhibitor, as a novel corrector for ΔF508-CFTR in cystic fibrosis through in silico screening and experimental validation.