A Stepwise Thiol Dioxygenation Mechanism in Mercaptosuccinate Dioxygenase Revealed by A Combined Experimental and Computational Study
Stephanie Jordan, Hannah Ralls, Henrik P. H. Wong, Jodan A Ernst, Todd C. Harrop, Sam P. de Visser, Yifan Wang
This study reveals the catalytic mechanism of mercaptosuccinate dioxygenase through combined experimental and computational methods, identifying a stepwise thiol dioxygenation pathway.
bioRxiv · May 21, 2026 · PreprintBiochemistry