BiophysicsbioRxivPreprint
Long-range electrostatic forces govern how proteins fold on the ribosome
Julian O. Streit, Sammy H. S. Chan, Charles Burridge…·John C. Christodoulou
The paper shows that electrostatic repulsion between the ribosome and nascent proteins inhibits co-translational folding, with net charge being the main determinant of folding thermodynamics.